Endocrine Abstracts

Objectives: Copper-64 (64Cu, T1/2=12.7 h; Eβ+ max =0.65 MeV (17.9%); Eβ− max =0.57 MeV (39%)) is suitable for in-vivo PET imaging. Prostate specific membrane antigen (PSMA) is significantly over-expressed in undifferentiated prostate cancer tissue. We report the initial molecular imaging results with 64Cu-PSMA PET/CT in patients with prostate cancer.Methods: 64Cu labeled PSMA (mean administered ra...

Hyperperhomocysteine has been implicated in vascular changes and oxidative stress contributing to endothelial dysfunction in preeclampsia. Our earlier studies have shown increased oxidative stress leading to reduced docosahexaenoic acid (DHA) levels in pre-eclamptic women. The present study examines the levels of angiogenic factors (VEGF, PlGF sFlt-1), homocysteine and oxidative stress marker malondialdehyde (MDA) levels, in 90 normotensive (control) and 137 preeclamptic women...

Methods: The diagnosis of Cushing’s Syndrome (CS) was made as per the prevalent endocrine society guidelines. CS patients with serum ACTH>15 pg/ml were considered as ACTH-dependent CS. Baseline ACTH (both inferior petrosal sinuses and peripheral) values were obtained, and since 2014, stimulated ACTH values (5 and 10 minutes post one unit iv vasopressin) were obtained as standard protocol. Prolactin corrected ACTH ratios were additionally being calculated since 2016. The h...

Aim: To analyze the safety, efficacy and dosimetry of Lu-177 labeled prostate specific membrane antigen (PSMA) ligand 617 in patients with progressive metastatic castration-resistant prostate cancer (mCRPC), in comparison with Lu-177 PSMA I&T.Methods: Lu-177 PSMA-617 radioligand therapy (PRLT) was performed in 64 mCRPC patients. The median administered activity per treatment was 6 GBq. Ga-68 PSMA PET/CT was used for patient selection and follow-up. H...

99mTc-Sestamibi (SeS) is a standard tool for localization of adenomas/hyperplasia (PA) in hyperparathyroidism (HPTH), designed on the difference between thyroid and parathyroid tissue radiotracer washout on early and late scintigraphy phases. However, PA have been reported to washout as fast as normal thyroid tissue (‘rapid washout’, RW), which may lead to diagnostic failure. The aim of the study was to determine a correlation of RW of SeS from parathyroid...

Introduction: Graves’ disease is associated with mild hypercalcemia in about 1/5th of cases. T3, through its nuclear receptor activates osteoclasts resulting in accelerated bone turnover. Although mild hypercalcemia is common in Graves’ disease, symptomatic hypercalcemia is rare. We describe a case who presented with thyrotoxic storm and hypercalcemia.Case report: 52-year-old lady presented with thyrotoxic symptoms of weight loss, dysphagia for...

Introduction: US Food and Drug Administration (FDA) has recently approved bexagliflozin, a new SGLT2 inhibitor. We examined the outcomes and metabolic effects of Bexagliflozin across the published Randomised Controlled Trials (RCCTs)Methods: A comprehensive literature search was done to extract publications from Medline-PubMed and Cochrane library, since inception till January 20, 2023, then screened and reviewed by two independent reviewers. Data includ...

Patients with haematological malignancies receiving neutropenia inducing chemotherapy sometimes have delayed discharge because of debility relating to complications of treatment. We assessed if these problems could be reduced by human growth hormone (GH) and also if haemopoetic recovery was quicker because stem cells have receptors for GH. In a randomized, double blind, placebo-controlled, trial patients were assigned to receive either GH, 250 mcg BD (n =75) or placebo (n =75)...